Light Chain Cardiac Amyloidosis. A case report and contribution of multi-modality imaging on diagnosis.
DOI:
https://doi.org/10.37615/retic.v6n2a5Keywords:
cardiac amyloidosis, AL amyloidosis, magnetic resonance, bone scintigraphyAbstract
Cardiac amyloidosis, considered previously as a rare disease, is now an illness to take into account in the diagnostic workup of patients with heart failure with preserved ejection fraction. The refinement of cardiac imaging techniques permits a timely diagnosis. There are clinical and imaging characteristics that orients into an etiology. We present a case of light chain cardiac amyloidosis, the clinical pearls that contributed to the diagnosis, and the systematic imaging workup.
Downloads
Metrics
References
Rodney H. Falk, Kevin M. Alexander, Ronglih Liao, Sharmila Dorbala. AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy. Journal of the American College of Cardiology, Volume 68, Issue 12,2016, Pages 1323-1341. doi: https://doi.org/10.1016/j.jacc.2016.06.053
Dorbala S, Ando Y, Bokhari S, Dispenzieri A, Falk RH, Ferrari VA, Fontana M, Gheysens O, Gillmore JD, Glaudemans AWJM, Hanna MA, Hazenberg BPC, Kristen AV, Kwong RY, Maurer MS, Merlini G, Miller EJ, Moon JC, Murthy VL, Quarta CC, Rapezzi C, Ruberg FL, Shah SJ, Slart RHJA, Verberne HJ, Bourque JM. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2-evidence base and standardized methods of imaging. J Nucl Cardiol. 2019 Dec;26(6):2065-2123. doi: https://doi.org/10.1007/s12350-019-01760-6
Pagourelias ED, Mirea O, Duchenne J, Van Cleemput J, Delforge M, Bogaert J, Kuznetsova T, Voigt JU. Echo Parameters for Differential Diagnosis in Cardiac Amyloidosis: A Head-to-Head Comparison of Deformation and Nondeformation Parameters. Circ Cardiovasc Imaging. 2017 Mar;10(3):e005588. doi:https://doi.org/10.1161/CIRCIMAGING.116.005588. PMID: 28298286
Baggiano A, Boldrini M, Martinez-Naharro A, Kotecha T, Petrie A, Rezk T, Gritti M, Quarta C, Knight DS, Wechalekar AD, Lachmann HJ, Perlini S, Pontone G, Moon JC, Kellman P, Gillmore JD, Hawkins PN, Fontana M. NoncontrastMagnetic Resonance for the Diagnosis of Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2020 Jan;13(1 Pt 1):69-80. doi: https://doi.org/10.1016/j.jcmg.2019.03.026 Epub 2019 Jun 12. PMID: 31202744
Dungu JN, Valencia O, Pinney JH, Gibbs SD, Rowczenio D, Gilbertson JA, Lachmann HJ, Wechalekar A, Gillmore JD, Whelan CJ, Hawkins PN, Anderson LJ. CMR-based differentiation of AL and ATTR cardiac amyloidosis. JACC Cardiovasc Imaging. 2014 Feb;7(2):133-42. doi: https://doi.org/10.1016/j.jcmg.2013.08.015. Epub 2014 Jan 8. PMID: 24412186
Kotecha T, Martinez-Naharro A, Treibel TA, Francis R, Nordin S, Abdel-Gadir A, Knight DS, Zumbo G, Rosmini S, Maestrini V, Bulluck H, Rakhit RD, Wechalekar AD, Gilbertson J, Sheppard MN, Kellman P, Gillmore JD, Moon JC, Hawkins PN, Fontana M. Myocardial Edema and Prognosis in Amyloidosis. J Am Coll Cardiol. 2018 Jun 26;71(25):2919-2931. doi: https://doi.org/10.1016/j.jacc.2018.03.536. PMID: 29929616.
Castano A, Haq M, Narotsky DL, et al. Multicenter study of planar technetium 99m pyrophosphate cardiac imaging: predicting survival for patients with ATTR cardiac amyloidosis. JAMA Cardiol 2016;1:880–9. doi: https://doi.org/10.1001/jamacardio.2016.2839
Paeng, J. C., & Choi, J. Y. (2021). Nuclear Imaging for Cardiac Amyloidosis: Bone Scan, SPECT/CT, and Amyloid-Targeting PET. Nuclear Medicine and Molecular Imaging, 55(2), 61–70. doi: https://doi.org/10.1007/s13139-020-00681-4
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Carlos Franco-Cruz, Jessica Mercedes, Verónica Gómez-Leiva, Luis Rivas
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
RETIC is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license https://creativecommons.org/licenses/by-nc-nd/4.0 which allows sharing, copying and redistribution of the material in any medium or format, under the following terms:
- Attribution: you must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests that the licensor endorses you or your use.
- Non-commercial: you may not use the material for commercial purposes.
- No Derivatives: if you remix, transform or build upon the material, you may not distribute the modified material.
- No Additional Restrictions: you may not apply legal terms or technological measures that legally restrict others from doing anything permitted by the license.
