FFR-CT as a useful tool for the detection of hemodynamically significant coronary lesions

Authors

  • Fanny Meylin Caballeros Lam Servicio de Radiología. Clínica Universidad de Navarra. España
  • Elena Refoyo Salicio Departamento de Cardiología y Cirugía Cardíaca. Clínica Universidad de Navarra. España
  • Gorka Bastarrika Alemañ Servicio de Radiología. Clínica Universidad de Navarra. España

DOI:

https://doi.org/10.37615/retic.v3n2a3

Keywords:

coronary artery disease, coronary computed tomography angiography, FFR-CT.

Abstract

Coronary computed tomography angiography is a non-invasive diagnostic method for the assessment of coronary artery disease. Despite its high sensitivity and negative predictive value, its specificity is low, especially to determine the functional significance of obstructive lesions. The calculation of fractional flow reserve using computed tomography angiography (FFR-CT) is an innovative method that allows, in the same study, the combination of anatomic and hemodynamic characteristics. Its use in routine clinical practice can be decisive in guiding therapeutic management, reducing unnecessary invasive tests and health costs.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Chinnaiyan KM, Akasaka T, Amano T, et al. Rationale, design and goals of the Heart Flow assessing diagnostic value of non invasive FFRCT in Coronary Care (ADVANCE) registry. J Cardiovasc Comput Tomogr 2017; 11 (1): 62-67.

Tesche C, De Cecco CN, Albrecht MH, et al. Coronary CT angiography derived fractional flow reserve. Radiology 2017; 285 (1): 17-33.

Lim SH, Flammer AJ, Yoon MH, et al. The long-term effect of coronary stent on epicardial and microvascular endothelial function. Circ Cardiovasc Interv 2012; 5 (4): 523-529.

Mathew RC, Gottbrecht M, Salerno M. Computed tomography fractional flow reserve to guide coronary angiography and intervention. Intervent Car- diol Clin 2018; 7 (3): 345-354.

Zimmermann FM, Ferrara A, Johnson NP, et al. Deferral vs. performance of percutaneous coronary intervention of functionally non-significant coronary stenosis: 15-year follow-up of the DEFER trial. Eur Heart J 2015; 36 (45): 3182-3188.

Zarins CK, Taylor CA, Min JK. Computed fractional flow reserve (FFTCT) derived from coronary CT angiography. J Cardiovasc Transl Res 2013; 6 (5): 708-714.

Toth GG, Toth B, Johnson NP, et al. Revascularization decisions in patients with stable angina and intermediate lesions: results of the international survey on interventional strategy. Circ Cardiovasc Interv 2014; 7 (6): 751- 759.

Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J 2020; 41 (3): 407- 477.

Knuuti J, Ballo H, Juarez-Orozco LE, et al. The performance of non invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: a meta-analysis focused on post-test disease probability. Eur Heart J 2018; 39 (35): 3322-3330.

Taylor CA, Fonte TA, Min JK. Computational fluid dynamics applied to cardiac computed tomography for noninvasive quantification of fractional flow reserve: scientific basis. J Am Coll Cardiol 2013; 61 (22): 2233-2241.

Ball C, Pontone G, Rabbat M. Fractional flow reserve derived from coronary computed tomography angiography datasets: the next frontier in non invasive assessment of coronary artery disease. Biomed Res Int 2018; 2018: 2680430.

Fairbairn TA, Nieman K, Akasaka T, et al. Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography derived fractional flow reserve: lessons from the ADVANCE Registry. Eur Heart J 2018; 39 (41): 3701-3711.

Patel MR, Nørgaard BL, Fairbairn TA, et al. 1-Year impact on medical practice and clinical outcomes of FFRCT The ADVANCE Registry. JACC Cardiovasc Imaging 2020; 13 (1 Pt 1): 97-105.

Kueh SH, Mooney J, Ohanaet M, et al. Fractional flow reserve derived from coronary computed tomography angiography reclassification rate using value distal to lesion compared to lowest value. J Cardiovasc Comput Tomo- gr 2017; 11 (6): 462-467

Published

2020-08-31

How to Cite

1.
Caballeros Lam FM, Refoyo Salicio E, Bastarrika Alemañ G. FFR-CT as a useful tool for the detection of hemodynamically significant coronary lesions. Rev Ecocardiogr Pract Otras Tec Imag Card (RETIC) [Internet]. 2020 Aug. 31 [cited 2024 Nov. 21];3(2):6-10. Available from: https://imagenretic.org/RevEcocarPract/article/view/217

Most read articles by the same author(s)