Cardiac amyloidosis through multimodality imaging
DOI:
https://doi.org/10.37615/retic.v1n2a10Keywords:
cardiac amyloidosis, cardiac imaging techniques.Abstract
Cardiac amyloidosis is a condition produced due to the deposition of amyloid in the heart. There are different subtypes of the disease that are caused by a variety of proteins. The most common types in developed countries are: light chain amyloidosis and transthyretin amyloidosis. Given its prognostic implications and the treatments that are being developed, it is necessary an accurate identification of the types of amyloidosis. The usual imaging techniques for diagnosis of this disease are echocardiography, cardiac resonance and 99Tc-DPD scintigraphy. In this article, we discuss the main tools that these techniques have contributed to identify the subtypes of amyloidosis.
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Dubrey SW, Hawkins PN, Falk RH. Amyloid diseases of the heart: assessment, diagnosis, and referral. Heart 2011; 97: 75-84. DOI: https://doi.org/10.1136/hrt.2009.190405
Gillmore JD, Maurer MS, Falk RH, et al. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Circulation 2016; 133: 2404-2412. DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.021612
Gertz, MA, Comenzo R, Falk RH, et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004. Am J Hematol 2005; 79: 319-328. DOI: https://doi.org/10.1002/ajh.20381
Grogan M, Scott CG, Kyle RA, et al. Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system. J Am Coll Cardiol 2016; 68: 1014-1020. DOI: https://doi.org/10.1016/j.jacc.2016.06.033
González-López E, Gagliardi C, Dominguez F, et al. Clinical characteristics of wildtype transthyretin cardiac amyloidosis: disproving myths. Eur Heart J 2017; 38: 1895-1904. DOI: https://doi.org/10.1093/eurheartj/ehx043
Quarta CC, Solomon SD, Uraizee I, et al. Left ventricular structure and function in transthyretin-related versus light-chain cardiac amyloidosis. Circulation 2014; 129: 1840-1849. DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.006242
Urbano-Moral JA, Gangadharamurthy D, Comenzo RL, et al. Ecocardiografía speckle tracking (rastreo de marcas) tridimensional en la amiloidosis cardiaca de cadenas ligeras: estudio de los parámetros de mecánica miocárdica ventricular izquierda y derecha. Rev Esp Cardiol 2015; 68: 657-664. DOI: https://doi.org/10.1016/j.recesp.2015.01.011
Puille M, Altland K, Linke RP, et al. 99mTc-DPD scintigraphy in transthyretin-related familial amyloidotic polyneuropathy. Eur J Nucl Med Mol Imaging 2002; 29: 376-379. DOI: https://doi.org/10.1007/s00259-001-0730-0
Peruggini E, Guidalotti PL, Salvi F, et al. Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mTc-3,3-diphosphono-1,2- propanodicarboxylic acid scintigraphy. J Am Coll Cardiol 2005; 46: 1076-1084. DOI: https://doi.org/10.1016/j.jacc.2005.05.073
De Haro-del Moral FJ, Sánchez-Lajusticia A, Gómez-Bueno M, et al. Papel de la gammagrafía cardiaca con 99mTc-DPD en la discriminación del subtipo de amiloidosis cardiaca. Rev Esp Cardiol 2012; 65: 440-446. DOI: https://doi.org/10.1016/j.recesp.2011.12.015
Longhi S, Guidalotti P, Quarta C, et al. Identification of TTR-Related Subclinical Amyloidosis With 99mTc-DPD Scintigraphy. JACC Cardiovasc Imaging 2014; 7: 531-532. DOI: https://doi.org/10.1016/j.jcmg.2014.03.004
Dorbala S, Vangala D, Semer J, et al. Imaging cardiac amyloidosis: a pilot study using 18F-florbetapir positrón emission tomography. Eur J Nucl Med Mol Imaging 2014; 41 (9): 1652-1662. DOI: https://doi.org/10.1007/s00259-014-2787-6
García-Gozález P, Zozar-Santiago MP, Maceira AM. Amiloidosis cardiaca detectada mediante PET/TC con 18F-florbetapir. Rev Esp Cardiol 2016; 69: 1215. DOI: https://doi.org/10.1016/j.recesp.2016.01.039
Maceira AM, Joshi J, Prasad SK, et al. Cardiovascular magnetic resonance in cardiac amyloidosis. Circulation 2005; 111: 186-193. DOI: https://doi.org/10.1161/01.CIR.0000152819.97857.9D
Fontana M, Banypersad SM, Treibel TA, et al. Differential Myocyte responses in patients with cardiac transthyretin amyloidosis and light-chain amyloidosis: a cardiac MR imaging study. Radiology 2015; 277: 388-397. DOI: https://doi.org/10.1148/radiol.2015141744
Pellikka PA, Holmes DR Jr, Edwards WD, et al. Endomyocardial biopsy in 30 patients with primary amyloidosis and suspected cardiac involvement. Arch Intern Med 1988; 148: 662-666. DOI: https://doi.org/10.1001/archinte.148.3.662
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Copyright (c) 2018 Inés Díaz-Dorronsoro , Joaquín Barba
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