Septal alcoholization in obstructive hypertrophic cardiomyopathy. Septal staining with saline solution as an alternative to echo-enhancers

Authors

  • Miguel Ángel Tibaldi Servicio de Cardiología, sede Cerro. Sanatorio Allende. Córdoba. Argentina.
  • Mayra Florencia Valdez Servicio de Cardiología, sede Cerro. Sanatorio Allende. Córdoba. Argentina.
  • Natalia Romero Servicio de Cardiología, sede Cerro. Sanatorio Allende. Córdoba. Argentina.
  • Judith Mailén Vicentin Servicio de Cardiología, sede Cerro. Sanatorio Allende. Córdoba. Argentina.
  • Hugo Londero Servicio de Hemodinamia, Angiografía y Cardiología Intervencionista. Sanatorio Allende. Córdoba. Argentina.
  • Guillermo Pacheco Servicio de Hemodinamia, Angiografía y Cardiología Intervencionista. Sanatorio Allende. Córdoba. Argentina.

DOI:

https://doi.org/10.37615/retic.v8n1a3

Keywords:

ventricular outflow obstruction, transesophageal echocardiography, heart failure

Abstract

Hypertrophic cardiomyopathy (HCM) is a myocardial disease caused by monogenic sarcomeric mutations and characterized by unexplained hypertrophy of the left ventricle. When medical treatment is ineffective, a therapeutic alternative is septal thickness reduction, with surgical septal myomectomy being the choice when performed in high-volume and experienced centers. However, another less invasive option is septal alcoholization. We present two patients—with repeated hospitalizations for heart failure—who underwent septal alcoholization as an alternative to surgical myomectomy. The objective is to highlight and explain the appropriate selection of septal branches, using the injection of agitated physiological solution, without the need for high-cost and difficultto-access echo-enhancers.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Ommen SR, Mital S, Burke MA, et al. 2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology/ American heart association Joint committee on clinical Practice guidelines. Circulation. 2020;142(25):e558-e631. doi: https://doi.org/10.1161/CIR.0000000000000938

Pérez-Sánchez I, Romero-Puche A, García-Molina Sáez E, et al. Factors Influencing the Phenotypic Expression of Hypertrophic Cardiomyopathy in Genetic Carriers. Rev Esp Cardiol (Engl Ed). 2018;71(3):146-154. doi: https://doi.org/10.1016/j.rec.2017.06.002

Pasipoularides A. Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology. Int J Cardiol. 2017;230:384-401. doi: https://doi.org/10.1016/J.ijcard.2016.12.097

Gersh BJ, Maron BJ, Bonow RO, et al. 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2011;58(25):e212-60. doi: https://doi.org/10.1016/j.jacc.2011.06.011

Harmon KG, Drezner JA, Wilson MG, Sharma S. Incidence of sudden cardiac death in athletes: a state-of-the-art review. Heart. 2014;100(16):1227-34. doi: https://doi.org/10.1136/heartjnl-2014-093872.rep

Hegde SM, Lester SJ, Solomon SD, et al. Effect of Mavacamten on echocardiographic features in symptomatic patients with obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol. 2021;78(25):2518-2532. doi: https://doi.org/10.1016/j.jacc.2021.09.1381

Olivotto I, Oreziak A, Barriales-Villa R, et al. Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2020;396(10253):759-769. doi: 10.1016/S0140-6736(20)31792-X

Elliott PM, Gimeno JR, Tomé MT, et al. Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy. Eur Heart J. 2006;27(16):1933-41. doi: https://doi.org/10.1093/eurheartj/ehl041

Ho CY, Mealiffe ME, Bach RG, et al. Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy. J Am Coll Cardiol. 2020;75(21):2649-2660. doi: https://doi.org/10.1016/j.jacc.2020.03.064

Maron BJ, Desai MY, Nishimura RA, et al. Management of Hypertrophic Cardiomyopathy: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022;79(4):390-414. doi: https://doi.org/10.1016/j.jacc.2021.11.021

Hassenstein P, Storch HH, Schmitz W. Results of electrical pacing in patients with hypertrophic obstruction cardiomyopathy. Thoraxchir Vask Chir. 1975;23(5):496-8. doi:https://doi.org/10.1055/s-0028-1097017

Woo A, Williams WG, Choi R, et al. Clinical and echocardiographic determinants of long-term survival after surgical myectomy in obstructive hypertrophic cardiomyopathy. Circulation. 2005;111(16):2033-41. doi: https://doi.org/10.1161/01.CIR.0000162460.36735.71

Ferrazzi P, Spirito P, Iacovoni A, et al. Transaortic chordal cutting: mitral valve repair for obstructive hypertrophic cardiomyopathy with mild septal hypertrophy. J Am Coll Cardiol. 2015;66(15):1687-96. doi: https://doi.org/10.1016/j.jacc.2015.07.069

Sorajja P, Valeti U, Nishimura RA, et al. Outcome of alcohol septal ablation for obstructive hypertrophic cardiomyopathy. Circulation. 2008;118(2):131-9. doi: https://doi.org/10.1161/CIRCULATIONAHA.107.738740

Liebregts M, Faber L, Jensen MK, et al. Outcomes of Alcohol Septal Ablation in Younger Patients With Obstructive Hypertrophic Cardiomyopathy. JACC Cardiovasc Interv. 2017;10(11):1134-1143. doi: https://doi.org/10.1016/j.jcin.2017.03.030

Published

2025-04-24

How to Cite

1.
Tibaldi M Ángel, Valdez MF, Romero N, Vicentin JM, Londero H, Pacheco G. Septal alcoholization in obstructive hypertrophic cardiomyopathy. Septal staining with saline solution as an alternative to echo-enhancers. Rev Ecocardiogr Pract Otras Tec Imag Card (RETIC) [Internet]. 2025 Apr. 24 [cited 2025 Apr. 25];8(1):10-5. Available from: https://imagenretic.org/RevEcocarPract/article/view/716